In this chapter, we present essential building blocks for developing applications in the domain of the Tactile Internet. Our building blocks belong to the fields of (i) safe, secure, and scalable computing infrastructures; (ii) world capturing and modeling; and (iii) context adaptive software and self-explanation. They cover topics, such as resource allocation and scheduling, secure machine learning, network security, privacy, world modeling, programmability, and self-explanation of software. We will report about the current state of the art, open research questions, our methodology to approach them, and expected results.