Synthetic Data Generation in Hematology - Paving the Way for OMOP and FHIR Integration

Research output: Contribution to journalResearch articleContributedpeer-review

Abstract

This study advances the utility of synthetic study data in hematology, particularly for Acute Myeloid Leukemia (AML), by facilitating its integration into healthcare systems and research platforms through standardization into the Observational Medical Outcomes Partnership (OMOP) and Fast Healthcare Interoperability Resources (FHIR) formats. In our previous work, we addressed the need for high-quality patient data and used CTAB-GAN+ and Normalizing Flow (NFlow) to synthesize data from 1606 patients across four multicenter AML clinical trials. We published the generated synthetic cohorts, that accurately replicate the distributions of key demographic, laboratory, molecular, and cytogenetic variables, alongside patient outcomes, demonstrating high fidelity and usability. The conversion to the OMOP format opens avenues for comparative observational multi-center research by enabling seamless combination with related OMOP datasets, thereby broadening the scope of AML research. Similarly, standardization into FHIR facilitates further developments of applications, e.g. via the SMART-on-FHIR platform, offering realistic test data. This effort aims to foster a more collaborative research environment and facilitate the development of innovative tools and applications in AML care and research.

Details

Original languageEnglish
Pages (from-to)1472-1476
Number of pages5
JournalStudies in health technology and informatics
Volume316
Publication statusPublished - 22 Aug 2024
Peer-reviewedYes

External IDs

ORCID /0000-0002-1887-4772/work/166764624
ORCID /0000-0002-9888-8460/work/166764819
Scopus 85202002537

Keywords

Research priority areas of TU Dresden

DFG Classification of Subject Areas according to Review Boards

Keywords

  • Electronic Health Records, Health Information Interoperability, Hematology, Humans, Leukemia, Myeloid, Acute, Outcome Assessment, Health Care