Synthesis of highly functionalized dextran alkyl carbonates showing nanosphere formation

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Holger Wondraczek - , Friedrich Schiller University Jena (Author)
  • Thomas Elschner - , Friedrich Schiller University Jena (Author)
  • Thomas Heinze - , Friedrich Schiller University Jena (Author)

Abstract

Highly substituted dextran alkyl carbonates were synthesized applying different acylating agents. The influence of the reaction media and the alkyl chain length on the reaction efficiency was systematically studied. Moreover, fluoroformates were successfully adapted as highly efficient and easy to handle reagents for the synthesis of dextran alkyl carbonates. The products obtained were clearly described by means of NMR- and IR spectroscopy. The dextran esters form spherical nanoparticles of a size below 300 nm that might be applied for delivery of therapeutic- or imaging agents. (C) 2010 Elsevier Ltd. All rights reserved.

Details

Original languageEnglish
Pages (from-to)1112-1118
Number of pages7
JournalCarbohydrate polymers
Volume83
Issue number3
Publication statusPublished - 30 Jan 2011
Peer-reviewedYes
Externally publishedYes

External IDs

Scopus 78650262893

Keywords

Keywords

  • Dextran, Carbonate, Chloroformate, Fluoroformate, Polysaccharide, NMR, CYCLIC CARBONATES, AMINO-ACIDS, CHLOROFORMATE, FLUOROFORMATES, NANOPARTICLES, DERIVATIVES, EFFICIENT, PRODRUGS, KINETICS, ESTERS