Synthesis of hetero-polymer functionalized nanocarriers by combining surface-initiated ATRP and RAFT polymerization

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Xin Huang - , Leibniz Institute of Polymer Research Dresden (Author)
  • Nicole Hauptmann - , Leibniz Institute of Polymer Research Dresden, TUD Dresden University of Technology (Author)
  • Dietmar Appelhans - , Leibniz Institute of Polymer Research Dresden (Author)
  • Petr Formanek - , Leibniz Institute of Polymer Research Dresden (Author)
  • Simon Frank - , Leibniz Institute of Polymer Research Dresden (Author)
  • Stefan Kaskel - , Chair of Inorganic Chemistry I (Author)
  • Achim Temme - , Department of Neurosurgery (Author)
  • Brigitte Voit - , Chair of Organic Chemistry of Polymers, Leibniz Institute of Polymer Research Dresden (Author)

Abstract

Smart nanocarriers are created based on a bi-functional hetero-initiator for RAFT and ATRP technique, bi-functionalizing mesoporous silica nanoparticles with two polymer types. The pH-dependent behavior of PDEAEMA as the gatekeeper polymer is verified by electrokinetic measurements and a controlled release behavior is demonstrated using doxorubicin as the drug.

Details

Original languageEnglish
Pages (from-to)3579-3583
Number of pages5
JournalSmall
Volume8
Issue number23
Publication statusPublished - 7 Dec 2012
Peer-reviewedYes

External IDs

PubMed 22911545
ORCID /0000-0002-4531-691X/work/148607615
ORCID /0000-0001-5084-1180/work/173988680

Keywords

ASJC Scopus subject areas

Keywords

  • ATRP, bi-functionalization, mesoporous silica nanoparticles, nanocarriers, RAFT

Library keywords