Synthesis and in vitro release of gentamicin from CaMCM-41/PLLA composite microspheres
Research output: Contribution to book/conference proceedings/anthology/report › Conference contribution › Contributed › peer-review
Contributors
Abstract
Composite microspheres based on Ca-doped mesoporous silica and poly(L-lactic acid) (CaMCM-41/PLLA) were prepared by a solid-in-oil-in-water emulsion/solvent evaporation technique. Using gentamicin as a model drug, gentamicin was loaded in the microspheres by the adsorption method, and the in vitro release of gentamicin from the microspheres was evaluated in phosphorus buffer saline (PBS) solution at 37 °C. The results showed that the release rates of gentamicin from CaMCM-41/PLLA composite microspheres were much lower than that from pure PLLA microspheres. On the other hand, CaMCM-41 incorporation into PLLA had the ability to induce hydroxyapatite formation and deposited on the surface of CaMCM-41/PLLA composite microspheres during gentamicin releasing in PBS. Therefore, CaMCM-41/PLLA composite microspheres could potentially be used as a local drug release system for bone filling.
Details
Original language | English |
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Title of host publication | Ceramic Materials and Components for Energy and Environmental Applications - 9th Int. Symp. on Ceramic Materials for Energy and Environmental Applications and the 4th Laser Ceramics Symp. |
Publisher | American Ceramic Society |
Pages | 79-84 |
Number of pages | 6 |
ISBN (print) | 9780470408421 |
Publication status | Published - 2010 |
Peer-reviewed | Yes |
Publication series
Series | Ceramic transactions / American Ceramic Society |
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Volume | 210 |
ISSN | 1042-1122 |
Conference
Title | Ceramic Materials and Components for Energy and Environmental Applications - 9th International Symposium on Ceramic Materials for Energy and Environmental Applications and the 4th Laser Ceramics Symposium |
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Duration | 10 - 14 November 2008 |
City | Shanghai |
Country | China |