Subtle Differences in Brain Architecture in Patients with Congenital Anosmia

Research output: Contribution to journalResearch articleContributedpeer-review



People suffering from congenital anosmia show normal brain architecture although they do not have functional sense of smell. Some studies in this regard point to the changes in secondary olfactory cortex, orbitofrontal cortex (OFC), in terms of gray matter volume increase. However, diffusion tensor imaging has not been explored so far. We included 13 congenital anosmia subjects together with 15 controls and looked into various diffusion parameters like FA. Increased FA in bilateral OFC confirms the earlier studies reporting increased gray matter thickness. However, it is quite difficult to interpret FA in terms of gray matter volume. Increased FA has been seen with recovery after traumatic brain injury. Such changes in OFC point to the plastic nature of the brain.


Original languageEnglish
Pages (from-to)337-340
Number of pages4
JournalBrain topography
Issue number3
Publication statusPublished - May 2022

External IDs

PubMedCentral PMC9098554
Scopus 85127491620
unpaywall 10.1007/s10548-022-00895-z
Mendeley daaf7b65-9a19-33bc-936d-ae3fab279c12
ORCID /0000-0001-9713-0183/work/146645248
ORCID /0000-0003-1311-8000/work/158767508



  • Brain/diagnostic imaging, Diffusion Tensor Imaging, Gray Matter/diagnostic imaging, Humans, Magnetic Resonance Imaging, Olfaction Disorders/congenital, Orbitofrontal cortex, Plasticity, Congenital anosmia, Diffusion tensor imaging

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