Subjective memory impairment in glioma patients with curative radiotherapy

Research output: Contribution to journalResearch articleContributedpeer-review



BACKGROUND: Radiotherapy in patients with primary brain tumors may affect hippocampal structure and cause dyscognitive side-effects.

PATIENTS AND METHODS: Using structural MRI and comprehensive neurocognitive evaluation, we investigated associations between hippocampal structure and memory deficits in 15 patients with WHO grade 3 and grade 4 gliomas receiving standard radio(chemo)therapy.

RESULTS: We did not find changes in hippocampal thickness or cognitive abilities three months after completing radiotherapy. However, subjective memory impairment was associated with symptoms of depression, but not with objective memory performance, cortical thickness of the hippocampus or radiation dose.

CONCLUSIONS: Irrespective of whether there is a bidirectional relationship between affective changes and subjective cognitive dysfunction in these patients, depressive symptoms remain a target for intervention to improve their quality of life. The results of our pilot study highlight that future assessment of side effects of radiotherapy concerning memory should include assessments of depressive symptoms.


Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalRadiotherapy and Oncology
Early online date18 Apr 2022
Publication statusPublished - Jun 2022

External IDs

Scopus 85129340965
WOS 000808077200002
Mendeley 86dfaad4-0ab7-382b-98b4-40278715afcc
unpaywall 10.1016/j.radonc.2022.04.010
ORCID /0000-0002-7017-3738/work/142254020


Research priority areas of TU Dresden

Subject groups, research areas, subject areas according to Destatis


  • Hippocampus, MRI, Neurocognitive evaluation, Radiotherapy, Subjective memory impairment, Mri, Humans, Cognitive Dysfunction, Neuropsychological Tests, Pilot Projects, Memory Disorders/etiology, Quality of Life, Hippocampus/radiation effects, Glioma/pathology