Striatal GABA-MRS predicts response inhibition performance and its cortical electrophysiological correlates
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Response inhibition processes are important for performance monitoring and are mediated via a network constituted by different cortical areas and basal ganglia nuclei. At the basal ganglia level, striatal GABAergic medium spiny neurons are known to be important for response selection, but the importance of the striatal GABAergic system for response inhibition processes remains elusive. Using a novel combination of behavior al, EEG and magnetic resonance spectroscopy (MRS) data, we examine the relevance of the striatal GABAergic system for response inhibition processes. The study shows that striatal GABA levels modulate the efficacy of response inhibition processes. Higher striatal GABA levels were related to better response inhibition performance. We show that striatal GABA modulate specific subprocesses of response inhibition related to pre-motor inhibitory processes through the modulation of neuronal synchronization processes. To our knowledge, this is the first study providing direct evidence for the relevance of the striatal GABAergic system for response inhibition functions and their cortical electrophysiological correlates in humans.
Details
Original language | English |
---|---|
Pages (from-to) | 3555-3564 |
Number of pages | 10 |
Journal | Brain Structure and Function |
Volume | 220 |
Issue number | 6 |
Publication status | Published - 26 Nov 2015 |
Peer-reviewed | Yes |
External IDs
PubMed | 25156575 |
---|---|
ORCID | /0000-0002-2989-9561/work/160952559 |
Keywords
ASJC Scopus subject areas
Keywords
- EEG, GABA, Magnetic resonance spectroscopy, Response inhibition, Striatum