Stress generation and filament turnover during actin ring constriction

Research output: Contribution to journalResearch articleContributedpeer-review



We present a physical analysis of the dynamics and mechanics of contractile actin rings. In particular, we analyze the dynamics of ring contraction during cytokinesis in the Caenorhabditis elegans embryo. We present a general analysis of force balances and material exchange and estimate the relevant parameter values. We show that on a microscopic level contractile stresses can result from both the action of motor proteins, which cross-link filaments, and from the polymerization and depolymerization of filaments in the presence of end-tracking cross-linkers.


Original languageEnglish
Article numbere696
JournalPloS one
Issue number8
Publication statusPublished - 8 Aug 2007

External IDs

PubMedCentral PMC1936222
Scopus 36249018147
ORCID /0000-0002-7689-8617/work/142237012



  • Actin Cytoskeleton/metabolism, Animals, Caenorhabditis elegans/cytology, Cytokinesis/physiology, Cytoskeleton/metabolism, Embryo, Nonmammalian/cytology, Models, Theoretical, Molecular Motor Proteins/metabolism, Myosin Type II/genetics, Recombinant Fusion Proteins/genetics, Stress, Mechanical

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