Stress generation and filament turnover during actin ring constriction
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
We present a physical analysis of the dynamics and mechanics of contractile actin rings. In particular, we analyze the dynamics of ring contraction during cytokinesis in the Caenorhabditis elegans embryo. We present a general analysis of force balances and material exchange and estimate the relevant parameter values. We show that on a microscopic level contractile stresses can result from both the action of motor proteins, which cross-link filaments, and from the polymerization and depolymerization of filaments in the presence of end-tracking cross-linkers.
Details
Original language | English |
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Article number | e696 |
Journal | PloS one |
Volume | 2 |
Issue number | 8 |
Publication status | Published - 8 Aug 2007 |
Peer-reviewed | Yes |
External IDs
PubMedCentral | PMC1936222 |
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Scopus | 36249018147 |
ORCID | /0000-0002-7689-8617/work/142237012 |
Keywords
Keywords
- Actin Cytoskeleton/metabolism, Animals, Caenorhabditis elegans/cytology, Cytokinesis/physiology, Cytoskeleton/metabolism, Embryo, Nonmammalian/cytology, Models, Theoretical, Molecular Motor Proteins/metabolism, Myosin Type II/genetics, Recombinant Fusion Proteins/genetics, Stress, Mechanical