Stoffwechsel der Mutter vor und bei Schwangerschaftseintritt: Voraussetzungen für einen guten Start ins neue Leben

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

Abstract

Background: Maternal metabolism affects implantation, pregnancy, delivery, and long-term health of mother and child. Research question: What are the relevant aspects regarding congenital and acquired disorders of the metabolism that are important for a woman’s preconceptional and periconceptional health? Material and Methods: Reviews, meta-analyses, and recommendations published in the last 10 years on the topic of periconceptional metabolic health are presented. Results: Periconceptional health is now the focus of many basic research studies, especially in animal models or in the context of assisted reproduction. Regarding long-term effects of inborn errors of metabolism and acquired metabolic disorders, retrospective and increasingly prospective studies are available. Pathophysiological changes leading to increased long-term maternal and infant risks are presented. Conclusions: Preconception health has increasingly become a major part of preventive medicine. Not only negative pregnancy outcomes but also long-term adverse health effects for mother and child can be prevented by early detection and treatment of inborn errors of metabolism, as well as periconceptional optimization of weight, glucose metabolism, and thyroid function.

Translated title of the contribution
Maternal metabolism before and at onset of pregnancy
Optimal conditions for a good start into a new life

Details

Original languageGerman
Pages (from-to)101-110
Number of pages10
JournalGynakologische Endokrinologie
Volume20
Issue number2
Publication statusPublished - May 2022
Peer-reviewedYes

Keywords

Sustainable Development Goals

Keywords

  • Fetal health, Fetal programming, Hypothyroidism, Maternal health, Overweight

Library keywords