STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Melanie Grehn - , Universitätsklinikum Schleswig-Holstein - Campus Lübeck (Author)
  • Stefano Mandija - , University Medical Center (UMC) Utrecht (Author)
  • Marcin Miszczyk - , Maria Sklodowska-Curie Institute of Oncology (Author)
  • David Krug - , Universitätsklinikum Schleswig-Holstein - Campus Lübeck (Author)
  • Bartłomiej Tomasik - , Maria Sklodowska-Curie Institute of Oncology (Author)
  • Kristine E Stickney - , University Medical Center (UMC) Utrecht (Author)
  • Pino Alcantara - , Complutense University (Author)
  • Filippo Alongi - , University of Brescia (Author)
  • Matteo Anselmino - , Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino (Author)
  • Ricardo Salgado Aranda - , Hospital Clinico Universitario San Carlos (Author)
  • Brian V Balgobind - , University of Amsterdam (Author)
  • Judit Boda-Heggemann - , Heidelberg University of Education (Author)
  • Leif-Hendrik Boldt - , Charité – Universitätsmedizin Berlin (Author)
  • Nicola Bottoni - , Cardiology Arrhythmology Center (Author)
  • Jakub Cvek - , Geneva University Hospitals (Author)
  • Olgun Elicin - , University of Bern (Author)
  • Gaetano Maria De Ferrari - , Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino (Author)
  • Rutger J Hassink - , Utrecht University (Author)
  • Colien Hazelaar - , Maastricht University (Author)
  • Gerhard Hindricks - , Leipzig University (Author)
  • Coen Hurkmans - , Catharina Hospital (Author)
  • Cinzia Iotti - , Radiation Oncology Unit (Author)
  • Tomasz Jadczyk - , Medical University of Silesia in Katowice (Author)
  • Otakar Jiravsky - , Hospital Agel Trinec Podlesi , Masaryk University (Author)
  • Raphaël Jumeau - , University Hospital of Lausanne (Author)
  • Steen Buus Kristiansen - , Aarhus University Hospital (AUH) (Author)
  • Mario Levis - , Polytechnic University of Turin (Author)
  • Manuel Algara López - , Hospital del Mar (Author)
  • Julio Martí-Almor - , Hospital del Mar (Author)
  • Felix Mehrhof - , OncoRay - National Centre for Radiation Research in Oncology (Author)
  • Ditte Sloth Møller - , Aarhus University Hospital (AUH) (Author)
  • Giulio Molon - , IRCCS Ospedale Sacro Cuore Don Calabria (Author)
  • Alexandre Ouss - , Catharina Hospital (Author)
  • Petr Peichl - , Institute for Clinical and Experimental Medicine (Author)
  • Jiri Plasek - , University Hospital Ostrava (Author)
  • Pieter G Postema - , University of Amsterdam (Author)
  • Aurelio Quesada - , Hospital General Universitario de Valencia (Author)
  • Tobias Reichlin - , University of Bern (Author)
  • Roberto Rordorf - , IRCCS Fondazione Policlinico San Matteo - Pavia (Author)
  • Boris Rudic - , Heidelberg University of Education (Author)
  • Ardan M Saguner - , University Hospital Zurich (Author)
  • Rachel M A Ter Bekke - , Maastricht University (Author)
  • José López Torrecilla - , Hospital General Universitario de Valencia (Author)
  • Esther G C Troost - , OncoRay - National Center for Radiation Research in Oncology, Department of Radiotherapy and Radiooncology, University Hospital Carl Gustav Carus Dresden, OncoRay - National Centre for Radiation Research in Oncology (Author)
  • Viviana Vitolo - , National Center of Oncological Hadrontherapy (Fondazione CNAO) (Author)
  • Nicolaus Andratschke - , University Hospital Zurich (Author)
  • Katja Zeppenfeld - , Leiden University (Author)
  • Slawomir Blamek - , Maria Sklodowska-Curie Institute of Oncology (Author)
  • Martin Fast - , University Medical Center (UMC) Utrecht (Author)
  • Ludovica de Panfilis - , Bioethics Unit (Author)
  • Oliver Blanck - , Universitätsklinikum Schleswig-Holstein - Campus Lübeck (Author)
  • Etienne Pruvot - , University Hospital of Lausanne (Author)
  • Joost J C Verhoeff - , University Medical Center (UMC) Utrecht (Author)

Abstract

The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.

Details

Original languageEnglish
Pages (from-to)1284-1295
Number of pages12
JournalEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Volume25
Issue number4
Publication statusPublished - 15 Apr 2023
Peer-reviewedYes

External IDs

PubMedCentral PMC10105846
Scopus 85147553830

Keywords

Keywords

  • Arrhythmias, Cardiac, Catheter Ablation/adverse effects, Heart Ventricles, Humans, Prospective Studies, Tachycardia, Ventricular, Treatment Outcome

Library keywords