Peel 500 grams of potatoes; cover potatoes in sufcient water and bring to boil; when the water boils, reduce heat and keep simmering for 20 minutes; drain potatoes and serve. By following this recipe, you get boiled potatoes. You don’t expect fries, or khoresht-e gheymeh bademjan (eggplant stew). The same principle applies to imaging and its use by AI tools. Yet, this is often not the case. Imaging acquired using one scanner can be quite diferent from one acquired from the same patient using a scanner from another vendor. Worse, quantitative image analysis tools and workfows that purportedly perform the same analysis may produce markedly diferent results for the same image [1]. Such difculties prevent clinical translation of potentially useful AI tools and quantitative imaging biomarkers [2, 3].