The theoretical link between endogenous cultural institutions (ECIs) and the regulation of natural resource access and use in sub-Saharan Africa is re-gaining its position in theory and practice. This is partly explained by growing resource use inefficiency, linked to predominantly exogenous, centralized institutions. The current situation has rekindled interest to understand what is left of ECIs that can support natural resource use and management in several natural resource contexts, including protected areas. To provide answers to these questions, in-depth studies with a geographic orientation are required. Put succinctly, a spaio-temporal evidence base of ECIs around protected areas is relevant in today’s dispensation. Such evidence is required for rich natural resource and culturally diverse settings such as Cameroon—having over 250 ethnic groups. This paper explores space time dynamics of ECIs around two of Cameroon’s protected areas—Santchou and Bakossi landscapes. Specifically we: (i) identified and categorized ECIs linked to protected area management, (ii) analyzed their spatio-temporal dynamics and discuss their implications for protected area management. The study is informed by key informant interviews (N = 22) and focus group discussions (N = 6). Using descriptive statistics, the key resources around these protected areas were categorized. Furthermore, narratives and thematic analysis constituted the key element of qualitative analysis. In addition, an analysis of the spatial distribution of ECIs was conducted. Based on our analysis, we derived the following conclusions: (1) Institutions that assume an endogenous cultural nature in some communities potentially exhibit an exogenous origin with a perennial nature; while some ECIs may assume ephemeral to intermittent nature, despite being culturally embedded in communities. (2) While present day ECIs regulate the use of natural resources around protected areas, they were not initially set up for this purpose. (3) Even within the same ethnic group, ECIs exhibit spatio-temporal variations. The results suggest the need for Cameroon’s on-going revision of the legal framework to emphasize context-specific elements of ECI which could leverage protected area management.