Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

L. Kappos; A. Bar-Or; B.A.C. Cree; R.J. Fox; G. Giovannoni; R. Gold; P. Vermersch; D.L. Arnold; S. Arnould; T. Scherz; C. Wolf; E. Wallström; F. Dahlke; A. Achiron; L. Achtnichts; K. Agan; G. Akman-Demir; A.B. Allen; J.P. Antel; A.R. Antiguedad; M. Apperson; A.M. Applebee; G.I. Ayuso; M. Baba; O. Bajenaru; R. Balasa; B.P. Balci; M. Barnett; A. Bass; V.U. Becker; M. Bejinariu; F.T. Bergh; A. Bergmann; E. Bernitsas; A. Berthele; V. Bhan; F. Bischof; R.J. Bjork; G. Blevins; M. Boehringer; T. Boerner; R. Bonek; J.D. Bowen; A. Bowling; A.N. Boyko; C. Boz; V. Bracknies; S. Braune; V. Brescia Morra; B. Brochet; W. Brola; P.K. Brownstone; M. Brozman; D. Brunet; I. Buraga; M. Burnett; M. Buttmann; H. Butzkueven; J. Cahill; J.C. Calkwood; W. Camu; M. Cascione; G. Castelnovo; D. Centonze; J. Cerqueira; A. Chan; A. Cimprichova; S. Cohan; G. Comi; J. Conway; J.A. Cooper; J. Corboy; J. Correale; B. Costell; D.A. Cottrell; P.K. Coyle; M. Craner; L. Cui; L. Cunha; A. Czlonkowska; A.M. da Silva; J. de Sa; J. de Seze; M. Debouverie; J. Debruyne; D. Decoo; G. Defer; T. Derfuss; N.H. Deri; B. Dihenia; P. Dioszeghy; V. Donath; B. Dubois; M. Duddy; P. Duquette; G. Edan; H. Efendi; S. Elias; P.J. Emrich; B.C. Estruch; E.P. Evdoshenko; J. Faiss; A.S. Fedyanin; W. Feneberg; J. Fermont; O.F. Fernandez; F.C. Ferrer; K. Fink; H. Ford; C. Ford; A. Francia; M. Freedman; B. Frishberg; S. Galgani; G.P. Garmany; K. Gehring; J. Gitt; C. Gobbi; L.P. Goldstick; R.A. Gonzalez; F. Grandmaison; N. Grigoriadis; O. Grigorova; L.M.E. Grimaldi; J. Gross; K. Gross-Paju; M. Gudesblatt; D. Guillaume; J. Haas; V. Hancinova; A. Hancu; O. Hardiman; A. Harmjanz; F.R. Heidenreich; G.J.D. Hengstman; J. Herbert; M. Herring; S. Hodgkinson; O.M. Hoffmann; W.E. Hofmann; W.D. Honeycutt; L.H. Hua; D. Huang; Y. Huang; D. Huang; R. Hupperts; P. Imre; A.K. Jacobs; G. Jakab; E. Jasinska; K. Kaida; J. Kalnina; A. Kaprelyan; G. Karelis; D. Karussis; A. Katz; F.A. Khabirov; B. Khatri; T. Kimura; I. Kister; R. Kizlaitiene; E. Klimova; J. Koehler; A. Komatineni; A. Kornhuber; K. Kovacs; A. Koves; W. Kozubski; G. Krastev; L.B. Krupp; E. Kurca; C. Lassek; G. Laureys; L. Lee; E. Lensch; F. Leutmezer; H. Li; R.A. Linker; M. Linnebank; P. Liskova; C. Llanera; J. Lu; A. Lutterotti; J. Lycke; R. Macdonell; M. Maciejowski; M. Maeurer; R.V. Magzhanov; E.-M. Maida; L. Malciene; Y. Mao-Draayer; G.A. Marfia; C. Markowitz; V. Mastorodimos; K. Matyas; J. Meca-Lallana; J.A.G. Merino; I.G. Mihetiu; I. Milanov; A.E. Miller; A. Millers; M. Mirabella; M. Mizuno; X. Montalban; L. Montoya; M. Mori; S. Mueller; J. Nakahara; Y. Nakatsuji; S. Newsome; R. Nicholas; A.S. Nielsen; E. Nikfekr; U. Nocentini; C. Nohara; K. Nomura; M.M. Odinak; T. Olsson; B.W. van Oosten; C. Oreja-Guevara; P. Oschmann; J. Overell; A. Pachner; G. Panczel; M. Pandolfo; C. Papeix; L. Patrucco; J. Pelletier; R. Piedrabuena; M. Pless; U. Polzer; K. Pozsegovits; D. Rastenyte; S. Rauer; G. Reifschneider; R. Rey; S.A. Rizvi; D. Robertson; J.M. Rodriguez; D. Rog; H. Roshanisefat; V. Rowe; C. Rozsa; S. Rubin; S. Rusek; F. Saccà; T. Saida; A.V. Salgado; V.E.F. Sanchez; K. Sanders; M. Satori; D.V. Sazonov; E.A. Scarpini; E. Schlegel; M. Schluep; S. Schmidt; E. Scholz; H.M. Schrijver; M. Schwab; R. Schwartz; J. Scott; K. Selmaj; S. Shafer; B. Sharrack; I.A. Shchukin; Y. Shimizu; P. Shotekov; A. Siever; K.-O. Sigel; S. Silliman; M. Simo; M. Simu; V. Sinay; A.E. Siquier; A. Siva; O. Skoda; A. Solomon; M. Stangel; D. Stefoski; B. Steingo; I.D. Stolyarov; P. Stourac; K. Strassburger-Krogias; E. Strauss; O. Stuve; I. Tarnev; A. Tavernarakis; C.R. Tello; M. Terzi; V. Ticha; M. Ticmeanu; K. Tiel-Wilck; T. Toomsoo; N. Tubridy; M.J. Tullman; H. Tumani; P. Turcani; B. Turner; A. Uccelli; F.J.O. Urtaza; M. Vachova; A. Valikovics; S. Walter; B. Van Wijmeersch; L. Vanopdenbosch; J.R. Weber; S. Weiss; R. Weissert; P. Vermersch; T. West; H. Wiendl; S. Wiertlewski; B. Wildemann; B. Willekens; L.H. Visser; G. Vorobeychik; X. Xu; T. Yamamura; Y.N. Yang; S.M. Yelamos; M. Yeung; A. Zacharias; M. Zelkowitz; U. Zettl; M. Zhang; H. Zhou; U. Zieman; T. Ziemssen

doi:10.1016/S0140-6736(18)30475-6

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

L. Kappos - (Author)
A. Bar-Or - (Author)
B.A.C. Cree - (Author)
R.J. Fox - (Author)
G. Giovannoni - (Author)
R. Gold - (Author)
P. Vermersch - (Author)
D.L. Arnold - (Author)
S. Arnould - (Author)
T. Scherz - (Author)
C. Wolf - (Author)
E. Wallström - (Author)
F. Dahlke - (Author)
A. Achiron - (Author)
L. Achtnichts - (Author)
K. Agan - (Author)
G. Akman-Demir - (Author)
A.B. Allen - (Author)
J.P. Antel - (Author)
A.R. Antiguedad - (Author)
M. Apperson - (Author)
A.M. Applebee - (Author)
G.I. Ayuso - (Author)
M. Baba - (Author)
O. Bajenaru - (Author)
R. Balasa - (Author)
B.P. Balci - (Author)
M. Barnett - (Author)
A. Bass - (Author)
V.U. Becker - (Author)
M. Bejinariu - (Author)
F.T. Bergh - (Author)
A. Bergmann - (Author)
E. Bernitsas - (Author)
A. Berthele - (Author)
V. Bhan - (Author)
F. Bischof - (Author)
R.J. Bjork - (Author)
G. Blevins - (Author)
M. Boehringer - (Author)
T. Boerner - (Author)
R. Bonek - (Author)
J.D. Bowen - (Author)
A. Bowling - (Author)
A.N. Boyko - (Author)
C. Boz - (Author)
V. Bracknies - (Author)
S. Braune - (Author)
V. Brescia Morra - (Author)
B. Brochet - (Author)
W. Brola - (Author)
P.K. Brownstone - (Author)
M. Brozman - (Author)
D. Brunet - (Author)
I. Buraga - (Author)
M. Burnett - (Author)
M. Buttmann - (Author)
H. Butzkueven - (Author)
J. Cahill - (Author)
J.C. Calkwood - (Author)
W. Camu - (Author)
M. Cascione - (Author)
G. Castelnovo - (Author)
D. Centonze - (Author)
J. Cerqueira - (Author)
A. Chan - (Author)
A. Cimprichova - (Author)
S. Cohan - (Author)
G. Comi - (Author)
J. Conway - (Author)
J.A. Cooper - (Author)
J. Corboy - (Author)
J. Correale - (Author)
B. Costell - (Author)
D.A. Cottrell - (Author)
P.K. Coyle - (Author)
M. Craner - (Author)
L. Cui - (Author)
L. Cunha - (Author)
A. Czlonkowska - (Author)
A.M. da Silva - (Author)
J. de Sa - (Author)
J. de Seze - (Author)
M. Debouverie - (Author)
J. Debruyne - (Author)
D. Decoo - (Author)
G. Defer - (Author)
T. Derfuss - (Author)
N.H. Deri - (Author)
B. Dihenia - (Author)
P. Dioszeghy - (Author)
V. Donath - (Author)
B. Dubois - (Author)
M. Duddy - (Author)
P. Duquette - (Author)
G. Edan - (Author)
H. Efendi - (Author)
S. Elias - (Author)
P.J. Emrich - (Author)
B.C. Estruch - (Author)
E.P. Evdoshenko - (Author)
J. Faiss - (Author)
A.S. Fedyanin - (Author)
W. Feneberg - (Author)
J. Fermont - (Author)
O.F. Fernandez - (Author)
F.C. Ferrer - (Author)
K. Fink - (Author)
H. Ford - (Author)
C. Ford - (Author)
A. Francia - (Author)
M. Freedman - (Author)
B. Frishberg - (Author)
S. Galgani - (Author)
G.P. Garmany - (Author)
K. Gehring - (Author)
J. Gitt - (Author)
C. Gobbi - (Author)
L.P. Goldstick - (Author)
R.A. Gonzalez - (Author)
F. Grandmaison - (Author)
N. Grigoriadis - (Author)
O. Grigorova - (Author)
L.M.E. Grimaldi - (Author)
J. Gross - (Author)
K. Gross-Paju - (Author)
M. Gudesblatt - (Author)
D. Guillaume - (Author)
J. Haas - (Author)
V. Hancinova - (Author)
A. Hancu - (Author)
O. Hardiman - (Author)
A. Harmjanz - (Author)
F.R. Heidenreich - (Author)
G.J.D. Hengstman - (Author)
J. Herbert - (Author)
M. Herring - (Author)
S. Hodgkinson - (Author)
O.M. Hoffmann - (Author)
W.E. Hofmann - (Author)
W.D. Honeycutt - (Author)
L.H. Hua - (Author)
D. Huang - (Author)
Y. Huang - (Author)
D. Huang - (Author)
R. Hupperts - (Author)
P. Imre - (Author)
A.K. Jacobs - (Author)
G. Jakab - (Author)
E. Jasinska - (Author)
K. Kaida - (Author)
J. Kalnina - (Author)
A. Kaprelyan - (Author)
G. Karelis - (Author)
D. Karussis - (Author)
A. Katz - (Author)
F.A. Khabirov - (Author)
B. Khatri - (Author)
T. Kimura - (Author)
I. Kister - (Author)
R. Kizlaitiene - (Author)
E. Klimova - (Author)
J. Koehler - (Author)
A. Komatineni - (Author)
A. Kornhuber - (Author)
K. Kovacs - (Author)
A. Koves - (Author)
W. Kozubski - (Author)
G. Krastev - (Author)
L.B. Krupp - (Author)
E. Kurca - (Author)
C. Lassek - (Author)
G. Laureys - (Author)
L. Lee - (Author)
E. Lensch - (Author)
F. Leutmezer - (Author)
H. Li - (Author)
R.A. Linker - (Author)
M. Linnebank - (Author)
P. Liskova - (Author)
C. Llanera - (Author)
J. Lu - (Author)
A. Lutterotti - (Author)
J. Lycke - (Author)
R. Macdonell - (Author)
M. Maciejowski - (Author)
M. Maeurer - (Author)
R.V. Magzhanov - (Author)
E.-M. Maida - (Author)
L. Malciene - (Author)
Y. Mao-Draayer - (Author)
G.A. Marfia - (Author)
C. Markowitz - (Author)
V. Mastorodimos - (Author)
K. Matyas - (Author)
J. Meca-Lallana - (Author)
J.A.G. Merino - (Author)
I.G. Mihetiu - (Author)
I. Milanov - (Author)
A.E. Miller - (Author)
A. Millers - (Author)
M. Mirabella - (Author)
M. Mizuno - (Author)
X. Montalban - (Author)
L. Montoya - (Author)
M. Mori - (Author)
S. Mueller - (Author)
J. Nakahara - (Author)
Y. Nakatsuji - (Author)
S. Newsome - (Author)
R. Nicholas - (Author)
A.S. Nielsen - (Author)
E. Nikfekr - (Author)
U. Nocentini - (Author)
C. Nohara - (Author)
K. Nomura - (Author)
M.M. Odinak - (Author)
T. Olsson - (Author)
B.W. van Oosten - (Author)
C. Oreja-Guevara - (Author)
P. Oschmann - (Author)
J. Overell - (Author)
A. Pachner - (Author)
G. Panczel - (Author)
M. Pandolfo - (Author)
C. Papeix - (Author)
L. Patrucco - (Author)
J. Pelletier - (Author)
R. Piedrabuena - (Author)
M. Pless - (Author)
U. Polzer - (Author)
K. Pozsegovits - (Author)
D. Rastenyte - (Author)
S. Rauer - (Author)
G. Reifschneider - (Author)
R. Rey - (Author)
S.A. Rizvi - (Author)
D. Robertson - (Author)
J.M. Rodriguez - (Author)
D. Rog - (Author)
H. Roshanisefat - (Author)
V. Rowe - (Author)
C. Rozsa - (Author)
S. Rubin - (Author)
S. Rusek - (Author)
F. Saccà - (Author)
T. Saida - (Author)
A.V. Salgado - (Author)
V.E.F. Sanchez - (Author)
K. Sanders - (Author)
M. Satori - (Author)
D.V. Sazonov - (Author)
E.A. Scarpini - (Author)
E. Schlegel - (Author)
M. Schluep - (Author)
S. Schmidt - (Author)
E. Scholz - (Author)
H.M. Schrijver - (Author)
M. Schwab - (Author)
R. Schwartz - (Author)
J. Scott - (Author)
K. Selmaj - (Author)
S. Shafer - (Author)
B. Sharrack - (Author)
I.A. Shchukin - (Author)
Y. Shimizu - (Author)
P. Shotekov - (Author)
A. Siever - (Author)
K.-O. Sigel - (Author)
S. Silliman - (Author)
M. Simo - (Author)
M. Simu - (Author)
V. Sinay - (Author)
A.E. Siquier - (Author)
A. Siva - (Author)
O. Skoda - (Author)
A. Solomon - (Author)
M. Stangel - (Author)
D. Stefoski - (Author)
B. Steingo - (Author)
I.D. Stolyarov - (Author)
P. Stourac - (Author)
K. Strassburger-Krogias - (Author)
E. Strauss - (Author)
O. Stuve - (Author)
I. Tarnev - (Author)
A. Tavernarakis - (Author)
C.R. Tello - (Author)
M. Terzi - (Author)
V. Ticha - (Author)
M. Ticmeanu - (Author)
K. Tiel-Wilck - (Author)
T. Toomsoo - (Author)
N. Tubridy - (Author)
M.J. Tullman - (Author)
H. Tumani - (Author)
P. Turcani - (Author)
B. Turner - (Author)
A. Uccelli - (Author)
F.J.O. Urtaza - (Author)
M. Vachova - (Author)
A. Valikovics - (Author)
S. Walter - (Author)
B. Van Wijmeersch - (Author)
L. Vanopdenbosch - (Author)
J.R. Weber - (Author)
S. Weiss - (Author)
R. Weissert - (Author)
P. Vermersch - (Author)
T. West - (Author)
H. Wiendl - (Author)
S. Wiertlewski - (Author)
B. Wildemann - (Author)
B. Willekens - (Author)
L.H. Visser - (Author)
G. Vorobeychik - (Author)
X. Xu - (Author)
T. Yamamura - (Author)
Y.N. Yang - (Author)
S.M. Yelamos - (Author)
M. Yeung - (Author)
A. Zacharias - (Author)
M. Zelkowitz - (Author)
U. Zettl - (Author)
M. Zhang - (Author)
H. Zhou - (Author)
U. Zieman - (Author)
T. Ziemssen - , Department of Neurology (Author)

Details

Original language	English
Journal	The Lancet
Publication status	Published - 2018
Peer-reviewed	Yes

External IDs

Scopus	85044304126

Research Portal of the TU Dresden

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Contributors

Details

External IDs

Keywords