Due to their excellent mechanical properties sandwich panels with carbon fibre reinforced plastics (CRFP) face sheets and folded core structures are very interesting for future aircraft fuselage concepts. The complex failure behavior of sandwich structures, e.g. face sheet delamination and core crushing, must be analyzed for high reliability in service. This paper presents a numerical study of impact simulations considering the effects of uniaxial compressive pre-stress on the progressive damage propagation. Different load cases and boundary conditions are discussed.