In the constantly changing environment that characterizes our daily lives, the ability to predict and adapt to new circumstances is crucial. This study examines the influence of sequence and knowledge adaptiveness on predictive coding in skill learning and rewiring. Participants were exposed to two different visuomotor sequences with overlapping probabilities. By applying temporal decomposition and multivariate pattern analysis, we dissected the neural underpinnings across different levels of signal coding. The study provides neurophysiological evidence for the influence of knowledge adaptiveness on shaping predictive coding, revealing that these are intricately linked and predominantly manifest at the abstract and motor coding levels. These findings challenge the traditional view of a competitive relationship between learning context and knowledge, suggesting instead a hierarchical integration where their properties are processed simultaneously. This integration facilitates the adaptive reuse of existing knowledge in the face of new learning. By shedding light on the mechanisms of predictive coding in visuomotor sequences, this research contributes to a deeper understanding of how the brain navigates and adapts to environmental changes, offering insights into the foundational processes that underlie learning and adaptation in dynamic contexts.