Seltene Ursache einer hämorrhagischen Diathese: Diagnostik und perioperatives Management bei hereditärer Dysfibrinogenämie
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Before elective surgery, it is mandatory that a precise history be taken to detect increased hemorrhagic diathesis and that thrombocytes, Quick/INR, and aPTT be determined. If pathological levels are found, further laboratory tests are necessary after frequent causes (e.g., liver cirrhosis) have been excluded. Single-factor analysis for the von Willebrand's factor antigen and if necessary further tests to check for von Willebrand's syndrome (multimeric analysis) as well as platelet function tests should be performed. Dysfibrinogenemia is a rare coagulation disorder, which causes elevated INR. It shows a wide spectrum of clinical manifestations including thrombophilia, excessive bleeding, and even asymptomatic cases. We present a 72-year-old patient with asymptomatic dysfibrinogenemia who needed hip replacement due to arthrosis. Lowered fibrinogen levels were substituted prior to operation and the clinical course afterwards was uneventful under additional prophylactic anticoagulation in order to prevent thrombosis. The case report illustrates the interdisciplinary teamwork which is very important in the management of patients with coagulation disorders.
Translated title of the contribution | A rare coagulation disorder. Diagnostics and management in cases of hereditary dysfibrinogenemia |
---|
Details
Original language | German |
---|---|
Pages (from-to) | 230-234 |
Number of pages | 5 |
Journal | Internist |
Volume | 50 |
Issue number | 2 |
Publication status | Published - Feb 2009 |
Peer-reviewed | Yes |
External IDs
PubMed | 19043687 |
---|
Keywords
ASJC Scopus subject areas
Keywords
- Coagulation disorders, Hereditary dysfibrinogenemia, Hypofibrinogenemia, Perioperative management