Self-organized patterning of cell morphology via mechanosensitive feedback
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Tissue organization is often characterized by specific patterns of cell morphology. How such patterns emerge in developing tissues is a fundamental open question. Here, we investigate the emergence of tissue-scale patterns of cell shape and mechanical tissue stress in the Drosophila wing imaginal disc during larval development. Using quantitative analysis of the cellular dynamics, we reveal a pattern of radially oriented cell rearrangements that is coupled to the buildup of tangential cell elongation. Developing a laser ablation method, we map tissue stresses and extract key parameters of tissue mechanics. We present a continuum theory showing that this pattern of cell morphology and tissue stress can arise via self-organization of a mechanical feedback that couples cell polarity to active cell rearrangements. The predictions of this model are supported by knockdown of MyoVI, a component of mechanosensitive feedback. Our work reveals a mechanism for the emergence of cellular patterns in morphogenesis.
Details
Original language | English |
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Article number | e57964 |
Journal | eLife |
Volume | 10 |
Publication status | Published - Mar 2021 |
Peer-reviewed | Yes |
External IDs
PubMed | 33769281 |
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Keywords
ASJC Scopus subject areas
Keywords
- Ablation, Development, Drosophila, Mechanosensitivity, Morphogenesis, Morphology, MyosinVI, Patterning, Self-organization, Wing