Schmerztherapie durch kutane Applikationsformen

Research output: Contribution to journalReview articleContributedpeer-review


  • T. Dimski - , Uniklinik Köln (Author)
  • F. Elsner - (Author)
  • L. Radbruch - (Author)
  • R. Sabatowski - , Uniklinik Köln (Author)


Up to a few years ago the transdermal application of analgesics to treat chronic and tumour-induced pain only was possible within the limits of a local therapy. Thereby topically acting substances like local anaesthetics, nonsteroidal antiphlogistics or capsaicin were used. Through the introduction of transdermal therapeutic systems (TTS) with opioids an efficient and reliable systemic opioid therapy with fentanyl was made possible in 1995, and also with transdermally applied buprenorphin in 2001. Not only because of the long application intervals and the simple administration the available systems represent a good alternative to the retarded, orally administered opioids on stable pain conditions with permanent opioid demand. With regard to the side effects, these systems only tend to have advantages compared to orally administered opioids.

Translated title of the contribution
Pain therapy with cutaneous dosage forms


Original languageGerman
Pages (from-to)171-181
Number of pages11
JournalTägliche Praxis : die Zeitschrift für Allgemeinmedizin
Issue number1
Publication statusPublished - Mar 2004
Externally publishedYes


ASJC Scopus subject areas


  • Buprenorphine, Cancer pain, Fentanyl, Non-cancer pain, Transdermal opioids