We consider an expressive description logic (DL) in which the global and local cardinality constraints introduced in previous papers can be mixed. On the one hand, we show that this does not increase the complexity of satisfiability checking and other standard inference problems. On the other hand, conjunctive query entailment in this DL turns out to be undecidable. We prove that decidability of querying can be regained if global and local constraints are not mixed and the global constraints are appropriately restricted.