SARS-CoV-2 Infections and Presymptomatic Type 1 Diabetes Autoimmunity in Children and Adolescents from Colorado, USA, and Bavaria, Germany

Research output: Contribution to journal › Letter › Contributed › peer-review

Contributors

  • Marian Rewers - , University of Colorado Anschutz Medical Campus (Author)
  • Ezio Bonifacio - , Center for Regenerative Therapies Dresden, Chair of Preclinical stem cell therapy and diabetes (Author)
  • Dominik Ewald - , Association of Pediatrician and Adolescent physicians (Author)
  • Cristy Geno Rasmussen - , University of Colorado Anschutz Medical Campus (Author)
  • Xiaofan Jia - , University of Colorado Anschutz Medical Campus (Author)
  • Laura Pyle - , University of Colorado Anschutz Medical Campus (Author)
  • Anette Gabriele Ziegler - , Helmholtz Zentrum München - German Research Center for Environmental Health (Author)

Abstract

An increased incidence of clinical diabetes has been reported in children with previous COVID-19.1,2 It is plausible that the virus may trigger autoimmune response to the islets or hasten metabolic decompensation in persons with already established islet autoimmunity. We tested the hypothesis that previous SARS-CoV-2 infection was associated with autoimmunity, which predicts future type 1 diabetes.

Details

Original languageEnglish
Pages (from-to)1252-1255
Number of pages4
JournalJAMA
Volume328
Issue number12
Publication statusPublished - 27 Sept 2022
Peer-reviewedYes

External IDs

PubMed 35930271
ORCID /0000-0002-8704-4713/work/141544363

Keywords

Research priority areas of TU Dresden

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

  • Adolescent, Asymptomatic Diseases/epidemiology, Autoimmunity, COVID-19/epidemiology, Child, Colorado/epidemiology, Diabetes Mellitus, Type 1/epidemiology, Germany/epidemiology, Humans, SARS-CoV-2

Library keywords