Same salience, different consequences: Disturbed inter-network connectivity during a social oddball paradigm in major depressive disorder
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
BACKGROUND: So far findings on emotional face processing among depressed individuals reveal an inconsistent image, with only some studies supporting a mood-congruent bias in salience processing. Thereby, many results are based on the processing of sad emotions and mostly focused on resting-state connectivity analysis. The present study aimed to target this misbalance by implementing a social oddball paradigm, with a special focus on the amygdala, the ACC, the insula and subdivisions of insula and ACC.
METHODS: Twenty-seven depressed patients and twenty-seven non-depressed controls took part in a fMRI event-related social oddball paradigm based on smiling facial expressions as target stimuli embedded in a stream of neutral facial expressions. FMRI activation and functional connectivity analysis were calculated for the pre-defined ROIs of the salience network (SN), with a special focus on twelve insular subdivisions and six ACC subdivisions.
RESULTS: For both groups the social oddball paradigm triggered similar BOLD responses within the pre-defined ROIs, while the quality of functional connectivity showed pronounced alterations from the salience network to the ventral attention- and default mode network (DMN).
CONCLUSION: On a first level of target detection, smiling faces are equally processed and trigger similar bold responses in structures of the salience network. On a second level of inter-network communication the brain of depressed participants tends to be pre-formed for self-referential processing and rumination instead of fast goal directed behavior and socio-emotional cognitive processing.
Details
Original language | English |
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Pages (from-to) | 102731 |
Journal | NeuroImage. Clinical |
Volume | 31 |
Publication status | Published - 2021 |
Peer-reviewed | Yes |
External IDs
PubMedCentral | PMC8234357 |
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Scopus | 85108412816 |
Keywords
Keywords
- Cerebral Cortex, Depressive Disorder, Major/diagnostic imaging, Facial Expression, Facial Recognition, Humans, Magnetic Resonance Imaging