Rolle des Hämoxygenase-CD163-Signalwegs beim abdominellen Aortenaneurysma

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Most abdominal aortic aneurysms (AAA) are covered by an intraluminal thrombus (ILT), which contains erythrocytes among other components. Hemolysis of erythrocytes releases hemoglobin, which forms reactive oxygen species (ROS) that have a damaging effect on the vessel wall. To prevent this, hemoglobin is bound to haptoglobin, taken up via the surface receptor CD163 and degraded by the antioxidant enzyme heme oxygenase‑1 (HO-1). The induction of the CD163-HO‑1 system is a feature of MHem macrophages, the role of which has already been demonstrated in connection with arteriosclerotic diseases. In AAAs, CD163-positive cells are mainly found in areas with increased iron deposition and CD163 expression increases during the course of the disease until AAA rupture. Furthermore, an increase in CD163 is associated with an increase in a number of protective antioxidant genes, such as HO‑1. In addition, an increase in soluble CD163 and HO‑1 has been found in serum and plasma samples from AAA patients. Further studies are needed to investigate whether the increased expression of components of the CD163-HO‑1 system in AAA can counteract local inflammation, iron-related ROS production and prevent disease progression.

Translated title of the contribution
Role of the heme oxygenase-CD163 signaling pathway in abdominal aortic aneurysms

Details

Original languageGerman
JournalZeitschrift fur Herz-, Thorax- und Gefasschirurgie
Publication statusPublished - 2024
Peer-reviewedYes

External IDs

Mendeley b451ca4c-e2ed-3649-9766-e5dc2a0f6d7d

Keywords

Keywords

  • Antioxidative, Inflammation, Intraluminal thrombus, Macrophages, Reactive oxygen species