Role of neuropilin-2 in the immune system

Research output: Contribution to journalReview articleContributedpeer-review



Neuropilins (NRPs) are single transmembrane receptors with short cytoplasmic tails and are dependent on receptors like VEGF receptors or Plexins for signal transduction. NRPs are known to be important in angiogenesis, lymphangiogenesis, and axon guidance. The Neuropilin-family consists of two members, Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2). They are up to 44 % homologous and conserved in all vertebrates. High levels of NRP2 are found on immune cells. Current research is very limited regarding the functions of NRP2 on these cells. Recent evidence suggests that NRP2 is important for migration, antigen presentation, phagocytosis and cell–cell contact within the immune system. Additionally, posttranslational NRP2 modifications like polysialylation are crucial for the function of some immune cells. This review is an overview about expression and functions of NRP2 in the immune system.


Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalMolecular Immunology
Publication statusPublished - Oct 2017

External IDs

Scopus 85028029069
researchoutputwizard legacy.publication#79254
PubMed 28843905
ORCID /0000-0001-7803-1972/work/142235066


ASJC Scopus subject areas


  • Neuropilin-2, Polysialylation