Rising from the ashes: cellular senescence in regeneration

Research output: Contribution to journalReview articleInvitedpeer-review



Cellular senescence has recently become causally implicated in pathological ageing. Hence, a great deal of research is currently dedicated towards developing senolytic agents to selectively kill senescent cells. However, senescence also plays important roles in a range of physiological processes including during organismal development, providing a barrier to tumorigenesis and in limiting fibrosis. Recent evidence also suggests a role for senescence in coordinating tissue remodelling and in the regeneration of complex structures. Through its non-cell-autonomous effects, a transient induction of senescence may create a permissive environment for remodelling or regeneration through promoting local proliferation, cell plasticity, tissue patterning, balancing growth, or indirectly through finely tuned interactions with infiltrating immune mediators. A careful analysis of the beneficial roles of cellular senescence may provide insights into important physiological processes as well as informing strategies to counteract its detrimental consequences in ageing and disease.


Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalCurrent opinion in genetics & development : reviews of all advances ; evaluation of key references ; comprehensive listing of papers
Publication statusPublished - Oct 2020

External IDs

Scopus 85088509189



  • Aging, Animals, Cell Plasticity, Cellular Senescence, Humans, Neoplasms/pathology, Regeneration