Review on Pediatric Malignant Focal Liver Lesions with Imaging Evaluation: Part I

Research output: Contribution to journalReview articleContributedpeer-review


  • Yi Dong - , Shanghai Jiao Tong University (Author)
  • Andrius Cekuolis - , Vilnius University Hospital Santaros Klinikos (Author)
  • Dagmar Schreiber-Dietrich - , Localinomed and Pediatric Department (Author)
  • Rasa Augustiniene - , Vilnius University Hospital Santaros Klinikos (Author)
  • Simone Schwarz - , Department of Child and Adolescent Psychiatry and Psychotherapy (Author)
  • Kathleen Möller - , SANA Hospital Lichtenberg (Author)
  • Nasenien Nourkami-Tutdibi - , University Hospital of Saarland (Author)
  • Sheng Chen - , Shanghai Jiao Tong University (Author)
  • Jia-Ying Cao - , Shanghai Jiao Tong University (Author)
  • Yun-Lin Huang - , Shanghai Jiao Tong University (Author)
  • Ying Wang - , Shanghai Jiao Tong University (Author)
  • Heike Taut - , Department of Paediatrics (Author)
  • Lara Grevelding - , Goethe University Frankfurt a.M. (Author)
  • Christoph F Dietrich - , Department Allgemeine Innere Medizin (DAIM) (Author)


Malignant focal liver lesions (FLLs) are commonly reported in adults but rarely seen in the pediatric population. Due to the rarity, the understanding of these diseases is still very limited. In children, most malignant FLLs are congenital. It is very important to choose appropriate imaging examination concerning various factors. This paper will outline common pediatric malignant FLLs, including hepatoblastoma, hepatocellular carcinoma, and cholangiocarcinoma and discuss them against the background of the latest knowledge on comparable/similar tumors in adults. Medical imaging features are of vital importance for the non-invasive diagnosis and follow-up of treatment of FLLs in pediatric patients. The use of CEUS in pediatric patients for characterizing those FLLs that remain indeterminate on conventional B mode ultrasounds may be an effective option in the future and has great potential to be integrated into imaging algorithms without the risk of exposure to ionizing radiation.


Original languageEnglish
Article number3568
Issue number23
Publication statusPublished - 29 Nov 2023

External IDs

PubMedCentral PMC10706220
Scopus 85179302079