RETRACTED: Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
We have identified a zebrafish homolog of the F3/F11/contactin (F3) recognition molecule. The gene shares 55% amino acid identity with F3 molecules in other vertebrates. Expression of F3 mRNA is first detectable at 16 h post-fertilization (hpf) in trigeminal and Rohon-Beard neurons. At 18-24 hpf, additional weaker expression is present in discrete cell clusters in the hindbrain, in the anterior lateral line/acoustic ganglion and in spinal motor neurons. Transcription factors of the LIM homeodomain class (LIM-HD) and their associated cofactors CLIM/ NLI/Ldb (CLIM) have been implicated in the development of peripheral axons of trigeminal and Rohon-Beard neurons. We demonstrate that ectopic overexpression of a dominant-negative CLIM molecule early during zebrafish development strongly reduces expression of F3 mRNA in these neurons indicating regulation of F3 by the LIM-HD protein network. These results and the spatiotemporal correlation of F3 expression with axonal differentiation in a subset of primary neurons suggest an important role of F3 for axon growth.
Details
Original language | English |
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Pages (from-to) | 137-143 |
Number of pages | 7 |
Journal | Gene Expression Patterns |
Volume | 2 |
Issue number | 1-2 |
Publication status | Published - Nov 2002 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 12617852 |
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Keywords
ASJC Scopus subject areas
Keywords
- CLIM/NLI/Ldb cofactors, Immunoglobulin-superfamily, Is1-1, L1.1, L1.2, LIM domain, Motor neurons, Rohon-Beard neurons, Trigeminal ganglion