Restoration of anatomical continuity after spinal cord transection depends on Wnt/β-catenin signaling in larval zebrafish

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Daniel Wehner - , University of Edinburgh (Author)
  • Thomas Becker - , University of Edinburgh (Author)
  • Catherina G. Becker - , University of Edinburgh (Author)

Abstract

This data article contains descriptive and experimental data on spinal cord regeneration in larval zebrafish and its dependence on Wnt/β-catenin signaling. Analyzing spread of intraspinally injected fluorescent dextran showed that anatomical continuity is rapidly restored after complete spinal cord transection. Pharmacological interference with Wnt/β-catenin signaling (IWR-1) impaired restoration of spinal continuity. For further details and experimental findings please refer to the research article by Wehner et al. Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish (Wehner et al., 2017) [1].

Details

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalData in brief
Volume16
Publication statusPublished - 4 Nov 2017
Peer-reviewedYes
Externally publishedYes

Keywords

ASJC Scopus subject areas

Keywords

  • Beta-catenin, Regeneration, Spinal cord, Wnt, Zebrafish

Library keywords