This research note explores opportunities for spatial planning to enhance the consideration of biodiversity and ecosystem services (ES) in Europe and Central Asia. We refer to and build on the regional assessment of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES). We find that a targeted and integrated approach to spatial planning can substantially enhance the conservation and sustainable use of biodiversity and ES. Spatial planning is a key instrument to explore spatial implications of combined policies on biodiversity and ES, and to design synergistic solution strategies. Together with other legal and regulatory instruments, spatial planning represents the backbone of policy mixes for biodiversity and ES delivery. Promising strategies for enhancing biodiversity and ES implementation in spatial planning include (i) mapping spatially explicit biodiversity and ES information in appropriate resolution, (ii) developing methods and tools for integrating this information in planning practice, and (iii) fostering delivery mechanisms.