Representation of published core outcome sets in practice guidelines

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Sarah Rhodes - , University of Manchester (Author)
  • Susanna Dodd - , University of Liverpool (UOL) (Author)
  • Stefanie Deckert - , Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus Dresden (Author)
  • Lenny Vasanthan - , Christian Medical College, University of Melbourne (Author)
  • Ruijin Qiu - , Beijing University of Chinese Medicine (Author)
  • Jeanett Friis Rohde - , University of Copenhagen (Author)
  • Ivan D. Florez - , Universidad de Antioquia, McMaster University, Clínica Las Américas (Author)
  • Jochen Schmitt - , Center for Evidence-Based Healthcare, University Hospital Carl Gustav Carus Dresden (Author)
  • Robby Nieuwlaat - , McMaster University (Author)
  • Jamie Kirkham - , University of Manchester (Author)
  • Paula R. Williamson - , University of Liverpool (UOL) (Author)

Abstract

Objectives: A core outcome set (COS) is an agreed standardized set of outcomes that should be measured and reported, as a minimum, in specific areas of health or health care. A COS is developed through a consensus process to ensure health care outcomes to be measured are relevant to decision-makers, including patients and health-care professionals. Use of COS in guideline development is likely to increase the relevance of the guideline to those decision-makers. Previous work has looked at the uptake of COS in trials, systematic reviews, health technology assessments and regulatory guidance but to date there has been no evaluation of the use of COS in practice guideline development. The objective of this study was to investigate the representation of core outcomes in a set of international practice guidelines. Study Design and Setting: We searched for clinical guidelines relevant to ten high-quality COS (with focus on the United Kingdom, Germany, China, India, Canada, Denmark, United States and World Health Organisation). We matched scope between COS and guideline in terms of condition, population and outcome. We calculated the proportion of guidelines mentioning or referencing COS and the proportion of COS domains specifically, or generally, matching to outcomes specified in each guideline populations, interventions, comparators and outcome (PICO) statement. Results: We found 38 guidelines that contained 170 PICO statements matching the scope of the ten COS and of sufficient quality to allow data extraction. None of the guidelines reviewed explicitly mentioned or referenced the relevant COS. The median (range) of the proportion of core outcomes covered either specifically or generally by the guideline PICO was 30% (0%–100%). Conclusion: There is no evidence that COS are being used routinely to inform the guideline development process, and concordance between outcomes in published guidelines and those in COS is limited. Further work is warranted to explore barriers and facilitators in the use of COS when developing clinical guidelines.

Details

Original languageEnglish
Article number111311
JournalJournal of clinical epidemiology
Volume169
Publication statusPublished - May 2024
Peer-reviewedYes

External IDs

PubMed 38423401

Keywords

ASJC Scopus subject areas

Keywords

  • COMET initiative, Clinical practice guidelines, Core outcome sets, Guideline development, Outcome measures, PICO, Outcome Assessment, Health Care/standards, Humans, Practice Guidelines as Topic/standards, Consensus