Reorganization of the functional connectome from rest to a visual perception task in schizophrenia and bipolar disorder
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Functional connectome organization is altered in schizophrenia (SZ) and bipolar disorder (BD). However, it remains unclear whether network reorganization during a task relative to rest is also altered in these disorders.This study examined connectome organization in patients with SZ (N = 43) and BD (N = 42) versus healthy controls (HC; N = 39) using fMRI data during a visual object-perception task and at rest. Graph analyses were conducted for the whole-brain network using indices selected a priori: three reflecting network segregation (clustering coefficient, local efficiency, modularity), two reflecting integration (characteristic path length, global efficiency).Group differences were limited to network segregation and were more evident in SZ (clustering coefficient, modularity) than in BD (clustering coefficient) compared to HC. State differences were found across groups for segregation (local efficiency) and integration (characteristic path length). There was no group-by-state inter-action for any graph index.In summary, aberrant network organization compared to HC was confirmed, and was more evident in SZ than in BD. Yet, reorganization was largely intact in both disorders. These findings help to constrain models of dys-connection in SZ and BD, suggesting that the extent of functional dysconnectivity in these disorders tends to persist across changes in mental state.
Details
Original language | English |
---|---|
Article number | 111556 |
Number of pages | 12 |
Journal | Psychiatry research. Neuroimaging |
Volume | 327 |
Early online date | Oct 2022 |
Publication status | Published - Dec 2022 |
Peer-reviewed | Yes |
External IDs
PubMed | 36327867 |
---|---|
Scopus | 85140451458 |
ORCID | /0000-0001-9298-2125/work/156337687 |
Keywords
Keywords
- Dysconnection, Graph analysis, Integration, Resting-state connectivity, Segregation, Task-based connectivity