Reorganization of the functional connectome from rest to a visual perception task in schizophrenia and bipolar disorder

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Philipp Riedel - , Department of Psychiatry and Psychotherapy, University of California at Los Angeles, TUD Dresden University of Technology (Author)
  • Junghee Lee - , University of California at Los Angeles, Department of Veterans Affairs, University of Alabama at Birmingham (Author)
  • Christopher G. Watson - , Baylor College of Medicine (Author)
  • Amy M. Jimenez - , University of California at Los Angeles, Department of Veterans Affairs (Author)
  • Eric A. Reavis - , University of California at Los Angeles, Department of Veterans Affairs (Author)
  • Michael F. Green - , University of California at Los Angeles, Department of Veterans Affairs (Author)

Abstract

Functional connectome organization is altered in schizophrenia (SZ) and bipolar disorder (BD). However, it remains unclear whether network reorganization during a task relative to rest is also altered in these disorders.This study examined connectome organization in patients with SZ (N = 43) and BD (N = 42) versus healthy controls (HC; N = 39) using fMRI data during a visual object-perception task and at rest. Graph analyses were conducted for the whole-brain network using indices selected a priori: three reflecting network segregation (clustering coefficient, local efficiency, modularity), two reflecting integration (characteristic path length, global efficiency).Group differences were limited to network segregation and were more evident in SZ (clustering coefficient, modularity) than in BD (clustering coefficient) compared to HC. State differences were found across groups for segregation (local efficiency) and integration (characteristic path length). There was no group-by-state inter-action for any graph index.In summary, aberrant network organization compared to HC was confirmed, and was more evident in SZ than in BD. Yet, reorganization was largely intact in both disorders. These findings help to constrain models of dys-connection in SZ and BD, suggesting that the extent of functional dysconnectivity in these disorders tends to persist across changes in mental state.

Details

Original languageEnglish
Article number111556
Number of pages12
JournalPsychiatry research. Neuroimaging
Volume327
Early online dateOct 2022
Publication statusPublished - Dec 2022
Peer-reviewedYes

External IDs

PubMed 36327867
Scopus 85140451458
ORCID /0000-0001-9298-2125/work/156337687

Keywords

Keywords

  • Dysconnection, Graph analysis, Integration, Resting-state connectivity, Segregation, Task-based connectivity