Introduction: Remote delivery of behavioral and lifestyle interventions has shown a great potential for achieving weight loss comparable to in-person treatment. However, little is known about its effects on adherence and efficacy in a real-world setting. During the COVID-19 pandemic, our usual care, a 12-month treatment program for morbid obesity, had to be transitioned to remote delivery. We evaluated whether this had adverse effects on weight loss or adherence. Methods: We report retrospective data of 234 patients who belonged either to a cohort affected by the transition of treatment delivery (N = 117, mean age = 44.2 years; BMI = 47.7 kg/m2) or to an individually matched control group treated prior to the pandemic (N = 117, 44.4 years; 47.3 kg/m2). Weight loss, dropouts, and attendance were compared between both groups and between remote and regular treatment periods. Results: Weight loss and the number of dropouts did not differ between the two groups and between treatment periods. However, attendance at remotely offered meetings was lower in the pandemic group (72.5%) when compared to the same meetings offered face to face in the control group (81.0%, p < 0.001). Discussion/Conclusion: Usual care weight loss and lifestyle interventions for morbid obesity can be successfully delivered via remote treatment.