Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
To determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was dependent on the chemokine receptors CCR2, CCR4, and CCR5 and P- and E-selectin ligands. In the allograft, Treg cells were activated and subsequently migrated to the draining lymph nodes (dLNs) in a CCR2, CCR5, and CCR7 fashion; this movement was essential for optimal suppression. Treg cells inhibited dendritic cell migration in a TGF-beta and IL-10 dependent fashion and suppressed antigen-specific T effector cell migration, accumulation, and proliferation in dLNs and allografts. These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 458-469 |
| Number of pages | 12 |
| Journal | Immunity |
| Volume | 30 |
| Issue number | 3 |
| Publication status | Published - 20 Mar 2009 |
| Peer-reviewed | Yes |
External IDs
| Scopus | 61949334905 |
|---|---|
| PubMed | 19303390 |
| PubMedCentral | PMC2737741 |
Keywords
Keywords
- Animals, Autoimmunity/immunology, Cell Movement/immunology, Cells, Cultured, Dendritic Cells/immunology, Inflammation, Islets of Langerhans/cytology, Lymph Nodes/immunology, Lymphocyte Subsets/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocytes, Regulatory/immunology