Regulation of β-cell function by RNA-binding proteins
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
β-cells of the pancreatic islets are highly specialized and high-throughput units for the production of insulin, the key hormone for maintenance of glucose homeostasis. Elevation of extracellular glucose and/or GLP-1 levels triggers a rapid upregulation of insulin biosynthesis through the activation of post-transcriptional mechanisms. RNA-binding proteins are emerging as key factors in the regulation of these mechanisms as well as in other aspects of β-cell function and glucose homeostasis at large, and thus may be implicated in the pathogenesis of diabetes. Here we review current research in the field, with a major emphasis on RNA-binding proteins that control biosynthesis of insulin and other components of the insulin secretory granules by modulating the stability and translation of their mRNAs.
Details
Original language | English |
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Pages (from-to) | 348-355 |
Number of pages | 8 |
Journal | Molecular metabolism |
Volume | 2 |
Issue number | 4 |
Publication status | Published - Nov 2013 |
Peer-reviewed | Yes |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- β-cells, Diabetes, Insulin, MRNA stability, RNA-binding proteins, Translation