Regional Associations of Cortical Superficial Siderosis and β-Amyloid-Positron-Emission-Tomography Positivity in Patients With Cerebral Amyloid Angiopathy

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Anika Finze - , Ludwig Maximilian University of Munich (Author)
  • Hannes Wahl - , Institute and Polyclinic of Diagnostic and Interventional Neuroradiology, University Hospital Carl Gustav Carus Dresden, TUD Dresden University of Technology (Author)
  • Daniel Janowitz - , Ludwig Maximilian University of Munich (Author)
  • Katharina Buerger - , Ludwig Maximilian University of Munich (Author)
  • Jennifer Linn - , Institute and Polyclinic of Diagnostic and Interventional Neuroradiology, University Hospital Carl Gustav Carus Dresden, TUD Dresden University of Technology (Author)
  • Axel Rominger - , University of Bern (Author)
  • Sophia Stöcklein - , Ludwig Maximilian University of Munich (Author)
  • Peter Bartenstein - , Ludwig Maximilian University of Munich, Munich Cluster for Systems Neurology (SyNergy) (Author)
  • Frank Arne Wollenweber - , Ludwig Maximilian University of Munich (Author)
  • Cihan Catak - , Ludwig Maximilian University of Munich (Author)
  • Matthias Brendel - , Ludwig Maximilian University of Munich, Munich Cluster for Systems Neurology (SyNergy), German Center for Neurodegenerative Diseases (DZNE) (Author)

Abstract

Objective: This is a cross-sectional study to evaluate whether β-amyloid-(Aβ)-PET positivity and cortical superficial siderosis (cSS) in patients with cerebral amyloid angiopathy (CAA) are regionally colocalized. Methods: Ten patients with probable or possible CAA (73.3 ± 10.9 years, 40% women) underwent MRI examination with a gradient-echo-T2*-weighted-imaging sequence to detect cSS and 18F-florbetaben PET examination to detect fibrillar Aβ. In all cortical regions of the Hammers Atlas, cSS positivity (MRI: ITK-SNAP segmentation) and Aβ-PET positivity (PET: ≥ mean value + 2 standard deviations of 14 healthy controls) were defined. Regional agreement of cSS- and Aβ-PET positivity was evaluated. Aβ-PET quantification was compared between cSS-positive and corresponding contralateral cSS-negative atlas regions. Furthermore, the Aβ-PET quantification of cSS-positive regions was evaluated in voxels close to cSS and in direct cSS voxels. Results: cSS- and Aβ-PET positivity did not indicate similarity of their regional patterns, despite a minor association between the frequency of Aβ-positive patients and the frequency of cSS-positive patients within individual regions (rs = 0.277, p = 0.032). However, this association was driven by temporal regions lacking cSS- and Aβ-PET positivity. When analyzing all composite brain regions, Aβ-PET values in regions close to cSS were significantly higher than in regions directly affected with cSS (p < 0.0001). However, Aβ-PET values in regions close to cSS were not different when compared to corresponding contralateral cSS-negative regions (p = 0.603). Conclusion: In this cross-sectional study, cSS and Aβ-PET positivity did not show regional association in patients with CAA and deserve further exploitation in longitudinal designs. In clinical routine, a specific cross-sectional evaluation of Aβ-PET in cSS-positive regions is probably not useful for visual reading of Aβ-PETs in patients with CAA.

Details

Original languageEnglish
Article number786143
JournalFrontiers in aging neuroscience
Volume13
Publication statusPublished - 3 Feb 2022
Peer-reviewedYes

External IDs

ORCID /0000-0002-4897-1119/work/146166943

Keywords

ASJC Scopus subject areas

Keywords

  • cerebral amyloid angiopathy, colocalization, cortical superficial siderosis, magnetic-resonance-imaging, positron-emission-tomography, topology, β-amyloid

Library keywords