Real-Time Monitoring of Blood Parameters in the Intensive Care Unit: State-of-the-Art and Perspectives

Research output: Contribution to journalReview articleContributedpeer-review


The number of patients in intensive care units has increased over the past years. Critically ill patients are treated with a real time support of the instruments that offer monitoring of relevant blood parameters. These parameters include blood gases, lactate, and glucose, as well as pH and tem-perature. Considering the COVID-19 pandemic, continuous management of dynamic deteriorating parameters in patients is more relevant than ever before. This narrative review aims to summarize the currently available literature regarding real-time monitoring of blood parameters in intensive care. Both, invasive and non-invasive methods are described in detail and discussed in terms of general advantages and disadvantages particularly in context of their use in different medical fields but especially in critical care. The objective is to explicate both, well-known and frequently used as well as relatively unknown devices. Furtehrmore, potential future direction in research and development of realtime sensor systems are discussed. Therefore, the discussion section provides a brief description of current developments in biosensing with special emphasis on their technical implementation. In connection with these developments, the authors focus on different electrochemical approaches to invasive and non-invasive measurements in vivo.


Original languageEnglish
Article number2408
Number of pages16
JournalJournal of clinical medicine
Issue number9
Publication statusPublished - Apr 2022

External IDs

Scopus 85128748849
PubMed 35566534
WOS 000800745000001
Mendeley 0e925fc2-d5a7-3317-a4a0-5a0221c8d444
unpaywall 10.3390/jcm11092408
ORCID /0000-0002-9899-1409/work/142249197
ORCID /0000-0003-3953-3253/work/142251739