PSMA-PET based radiotherapy: A review of initial experiences, survey on current practice and future perspectives

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Sebastian Zschaeck - , Charité – Universitätsmedizin Berlin (Author)
  • Fabian Lohaus - , Department of Radiotherapy and Radiooncology, TUD Dresden University of Technology, German Cancer Research Center (DKFZ) (Author)
  • Marcus Beck - , Charité – Universitätsmedizin Berlin (Author)
  • Gregor Habl - , Technical University of Munich, Helmholtz Centre for Environmental Research (Author)
  • Stephanie Kroeze - , University of Zurich (Author)
  • Constantinos Zamboglou - , University of Freiburg, German Cancer Research Center (DKFZ) (Author)
  • Stefan Alexander Koerber - , Heidelberg University , German Cancer Research Center (DKFZ) (Author)
  • Jürgen Debus - , Heidelberg University , German Cancer Research Center (DKFZ) (Author)
  • Tobias Hölscher - , Department of Radiotherapy and Radiooncology, TUD Dresden University of Technology, German Cancer Research Center (DKFZ) (Author)
  • Peter Wust - , Charité – Universitätsmedizin Berlin (Author)
  • Ute Ganswindt - , Innsbruck Medical University (Author)
  • Alexander D.J. Baur - , Charité – Universitätsmedizin Berlin (Author)
  • Klaus Zöphel - , TUD Dresden University of Technology (Author)
  • Nikola Cihoric - , University of Bern (Author)
  • Matthias Guckenberger - , University of Zurich (Author)
  • Stephanie E. Combs - , Technical University of Munich, Helmholtz Centre for Environmental Research, German Cancer Research Center (DKFZ) (Author)
  • Anca Ligia Grosu - , University of Freiburg, German Cancer Research Center (DKFZ) (Author)
  • Pirus Ghadjar - , Charité – Universitätsmedizin Berlin (Author)
  • Claus Belka - , Ludwig Maximilian University of Munich, German Cancer Research Center (DKFZ) (Author)

Abstract

68Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative intended therapy. Owed to the novelty of the PSMA-targeting tracers, clinical evidence on the value of PSMA-PET is moderate but rapidly increasing. State of the art imaging is pivotal for radiotherapy treatment planning as it may affect dose prescription, target delineation and use of concomitant therapy. This review summarizes the evidence on PSMA-PET imaging from a radiation oncologist's point of view. Additionally a short survey containing twelve examples of patients and 6 additional questions was performed in seven mayor academic centers with experience in PSMA ligand imaging and the findings are reported here.

Details

Original languageEnglish
Article number90
JournalRadiation oncology
Volume13
Issue number1
Publication statusPublished - 11 May 2018
Peer-reviewedYes

External IDs

PubMed 29751842

Keywords

Sustainable Development Goals

Keywords

  • Image guided treatment planning, Primary radiotherapy, Prostate-cancer, PSMA-PET, Review, Salvage radiotherapy, Survey