Prominin-1 (CD133): from progenitor cells to human diseases
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Prominin-1 (CD133) is a pentaspan membrane glycoprotein that binds to plasma membrane cholesterol and concentrates selectively in plasma membrane protrusions. In recent years, this molecule has received considerable interest due to its expression in various progenitors, including those derived from the neural and hematopoietic system, as well as in cancer originating from these systems. Prominin-1 is also the target of mutations leading to retinal degeneration. In the future, prominin-1-positive progenitor cells might become clinically significant, particularly with regard to tissue engineering, and prominin-1 itself might reveal some fundamental cell biological aspects concerning the self-renewal capacity of somatic stem cells
Details
Original language | English |
---|---|
Pages (from-to) | 213-225 |
Journal | FUTURE LIPIDOLOGY |
Volume | 1 |
Issue number | 2 |
Publication status | Published - Apr 2006 |
Peer-reviewed | Yes |
External IDs
ORCID | /0000-0003-1181-3659/work/142252243 |
---|
Keywords
Sustainable Development Goals
Keywords
- AC133 antigen, bone marrow transplantation, cancer, CD 133, cholesterol, hematopoietic, lipid raft, progenitors, prominin-1, retinal degeneration, stem cell marker