Prinzipien der postoperativen Therapie beim Rektumkrazinom
Research output: Contribution to journal › Research article › Invited › peer-review
Contributors
Abstract
In stage II (T3-4NO) and III (TxN1-2) rectal cancer,adjuvant radiochemotherapy improves overall survival and decreases the rate of local failure compared to only surgical therapy and is regarded as standard for patients with carcinoma of the lower and intermediate rectum. (Preoperative) radiotherapy also decreases the local failure rate following total mesorectal excision. Postoperative radiotherapy has no proven influence on distant metastasis rates or on overall survival. In adjuvant therapy, continuous infusion of 5-flourouracil compared to bolus application increases long-term survival. However, additional administration of leucovorin or levamisole results in increased toxicity and not improved survival. Results of randomized trials of adjuvant therapy with new drugs such as capecitabine, UFT, irinotecan,or oxaliplatin are not yet available. These drugs should not be used outside clinical trials. Elderly patients benefit from adjuvant therapy to the same extent as younger patients and should receive adjuvant radiochemotherapy, if no contraindication exists.
Translated title of the contribution | Principles of postoperative therapy in rectal carcinoma |
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Details
Original language | German |
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Pages (from-to) | 32–37 |
Number of pages | 6 |
Journal | Der Chirurg : Zeitschrift für alle Gebiete der operativen Medizin |
Volume | 75 |
Issue number | 1 |
Publication status | Published - Jan 2004 |
Peer-reviewed | Yes |
External IDs
PubMed | 14740125 |
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WOS | 000189037500006 |
Keywords
Sustainable Development Goals
Keywords
- Adjuvant therapy, Chemotherapy, Radiochemotherapy, Rectal cancer