Preparation of HOPO-containing lariate ethers based on the diaza-18-crown-6 scaffold

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Florian Paßler - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Linda Belke - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Falco Reissig - , Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Klaus Kopka - , Chair of Bioinorganic and Radiopharmaceutical Chemistry, Helmholtz-Zentrum Dresden-Rossendorf, TUD Dresden University of Technology (Author)
  • Constantin Mamat - , Helmholtz-Zentrum Dresden-Rossendorf, TUD Dresden University of Technology (Author)

Abstract

Cyclic and acyclic ligands containing the hydroxypyridinone (HOPO) moiety as donor group are known as strong coordinating compounds for a wide variety of metal ions. Based on the diaza-crown[18]ether Kryptofix K22, five different tendentate ligands were prepared using 1,2-HOPO, 1,2,3-HOPO and 2,3-Me-HOPO as additional binding moieties. The diaza-crown ether basic skeleton was furnished with two primary amine functions and subsequently reacted with the respective HOPO acids or the HOPO acid chlorides to obtain the desired HOPO derivatives in two synthesis steps after final deprotection. All compounds were evidenced by NMR and MS analyses.

Details

Original languageEnglish
Pages (from-to)4157-4164
Number of pages8
JournalChemical papers
Volume78
Issue number7
Publication statusPublished - May 2024
Peer-reviewedYes

Keywords