Predictors of subjective cognitive deficits in patients with mild cognitive impairment

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

BACKGROUND: Detailed examination of cognitive deficits in patients with mild cognitive impairment (MCI) yields substantial diagnostic and prognostic value, specifically with respect to memory. Magnitude and characteristics of subjective cognitive deficits, however, often receive less attention in this population at risk for developing dementia.

METHODS: We investigated predictors of subjective cognitive deficits in patients with MCI, using a detailed assessment for such impairments associated with different cognitive domains, as well as demographic and clinical variables including magnetic resonance imaging data.

RESULTS: The strongest predictor for subjective memory deficits was depressed mood, whereas subjective performance issues associated with attention or executive functions also corresponded to measurable impairments in the respective cognitive domains. Reduced hippocampal thickness and hemispheric entorhinal cortex thickness asymmetry were associated with objective memory impairment but not with subjective deficits or symptoms of depression.

CONCLUSIONS: Whereas low objective memory performance and reduced cortical thickness within medial temporal lobe subregions could be associated with neurodegeneration, greater subjective memory deficits in patients with MCI may indicate psychological burden.

Details

Original languageEnglish
Pages (from-to)210-217
Number of pages8
JournalPsychogeriatrics
Volume22
Issue number2
Publication statusPublished - 1 Mar 2022
Peer-reviewedYes

External IDs

Scopus 85121543181
Mendeley 67a04620-dc06-3784-bfcd-59ed5511c680
unpaywall 10.1111/psyg.12802
ORCID /0000-0001-9713-0183/work/146645265
ORCID /0000-0002-2936-5180/work/147674480
ORCID /0000-0001-8204-5699/work/156335424
ORCID /0000-0003-1311-8000/work/158767511

Keywords

Sustainable Development Goals

Keywords

  • hippocampus, magnetic resonance imaging, memory, mild cognitive impairment, subjective cognitive deficits

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