Präoperative Dignitätsbeurteilung asymptomatischer Adnextumoren mittels Positronen-Emissions-Tomographie und F-18-FluordeoxygIukose

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Sabine Fenchel - , Technical University of Munich (Author)
  • J. Kotzerke - , Ulm University (Author)
  • I. Stöhr - (Author)
  • D. Grab - (Author)
  • K. Nüssle - (Author)
  • A. Rieber - (Author)
  • R. Kreienberg - (Author)
  • H. J. Brambs - (Author)
  • S. N. Reske - (Author)

Abstract

Aim: To evaluate use of F-18-FDG-PET in assessment of dignity of asymptomatic adnexal masses. Methods: 85 asymptomatic patients with suspicious, asymptomatic adnexal masses were evaluated. Static FDG-PET (Exact HR+ or ECAT 931) imaging of the abdomen was performed following application of 222-555 MBq F-18-FDG. Iterative reconstruction was applied. PET data were analysed visually, at first without and second together with MRT images. Final diagnosis was made by histopathology. Results: FDG-PET allowed correct identification of 4 of 8 malignant adnexal tumors. False negative results were obtained in 2 adenocarcinomas stage pT1a and 2 borderline-tumors. In 60 out of 77 benign adnexal masses malignancy could be excluded. False positive FDG-uptake, partly because of misinterpretation of gastrointestinal activity, was found in 3 inflammatory processes, 1 teratoma, 1 benign schwannoma, 1 dermoid cyst, 1 benign thecoma, 1 serous cyst, 1 serous cystadenoma, 2 mucinous cystadenomas, 2 corpus luteum cysts, 3 endometriosic cysts and 1 sactosalpinx. The overall sensitivity and specifity of FDG-PET alone were 50% and 78%. Evaluation together with MRT images showed a sensitivity of 50% and a specifity of 86%. Conclusion: Sensitivity of FDG-PET in detection of borderline-tumors and early stage ovarian cancer seems to be limited. Low incidence of malignant ovarian tumors requires for assesment of dignity a procedure of high specifity, that is not reached by FDG-PET neither without nor together with MRT images for topographic orientation. Therefore use of FDG-PET for assesment of dignity in suspicious, asymptomatic ovarian tumors is limited.

Translated title of the contribution
Preoperative assessment of asymptomatic adnexal masses by positron emission tomography and F-18-Fluorodeoxyglucose

Details

Original languageGerman
Pages (from-to)101-107
Number of pages7
JournalNuklearmedizin
Volume38
Issue number4
Publication statusPublished - 1999
Peer-reviewedYes
Externally publishedYes

External IDs

PubMed 10392374

Keywords

Sustainable Development Goals

Keywords

  • Borderline-tumors, F-18-FDG, Ovarian tumors, Positron emission tomography

Library keywords