Potential of TCR sequencing in graft-versus-host disease

Research output: Contribution to journalReview articleContributedpeer-review

Abstract

Graft-versus-host disease (GvHD) remains one of the major complications following allogeneic haematopoietic stem cell transplantation (allo-HSCT). GvHD can occur in almost every tissue, with the skin, liver, and intestines being the mainly affected organs. T cells are implicated in initiating GvHD. T cells identify a broad range of antigens and mediate the immune response through receptors on their surfaces (T cell receptors, TCRs). The composition of TCRs within a T cell population defines the TCR repertoire of an individual, and this repertoire represents exposure to self and non-self proteins. Monitoring the changes in the TCR repertoire using TCR sequencing can provide an indication of the dynamics of a T cell population. Monitoring the frequency and specificities of specific TCR clonotypes longitudinally in different conditions and specimens (peripheral blood, GvHD-affected tissue samples) can provide insights into factors modulating immune reactions following allogeneic transplantation and will help to understand the underlying mechanisms mediating GvHD. This review provides insights into current studies of the TCR repertoire in GvHD and potential future clinical implications of TCR sequencing.

Details

Original languageEnglish
Number of pages8
JournalBone marrow transplantation
Volume2022
Issue number3
Publication statusPublished - 7 Dec 2022
Peer-reviewedYes

External IDs

WOS 000894988600002
Mendeley d33226f5-ed04-3131-a6c6-9ba33912e9cb
ORCID /0000-0002-8704-4713/work/141544378