Postradiogene Morphea – eine Übersicht
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
BACKGROUND: Radiation-induced morphea is a fibro-inflammatory remodelling process of the subcutaneous connective tissue caused by ionising radiation, most commonly in the context of breast cancer treatment. The underlying pathomechanisms and putative risk factors are unknown. Therefore, misdiagnosis and inappropriate treatment pose a significant problem in the care of those patients.
OBJECTIVES: The aim of the study was to provide an overview as well as guidance for the diagnosis and treatment of radiation-induced morphea based on current case reports and review articles.
RESULTS AND CONCLUSIONS: Radiation-induced morphea is a rare condition that represents an interdisciplinary challenge for (gynaecological) oncology, radiotherapy and dermatology. Frequent misdiagnoses include infection (erysipelas), cancer recurrence or radiation dermatitis. Early histological diagnosis and the initiation of anti-inflammatory therapy using topical glucocorticoids or calcineurin inhibitors in combination with phototherapy and/or methotrexate are the most relevant success factors for an adequate clinical response.
Translated title of the contribution | Radiation-induced morphea-an overview |
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Details
Original language | German |
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Pages (from-to) | 214-217 |
Number of pages | 4 |
Journal | Die Dermatologie : Zeitschrift für Dermatologie, Venerologie und verwandte Gebiete |
Volume | 75 |
Issue number | 3 |
Early online date | 19 Jan 2024 |
Publication status | Published - 19 Jan 2024 |
Peer-reviewed | Yes |
External IDs
ORCID | /0000-0002-4330-1861/work/151436388 |
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Scopus | 85182677667 |
Keywords
Sustainable Development Goals
Keywords
- Neoplasm Recurrence, Local/complications, Humans, Scleroderma, Localized/diagnosis, Breast Neoplasms/complications, Female, Methotrexate/adverse effects, Phototherapy/adverse effects