Postradiogene Morphea – eine Übersicht

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

Abstract

BACKGROUND: Radiation-induced morphea is a fibro-inflammatory remodelling process of the subcutaneous connective tissue caused by ionising radiation, most commonly in the context of breast cancer treatment. The underlying pathomechanisms and putative risk factors are unknown. Therefore, misdiagnosis and inappropriate treatment pose a significant problem in the care of those patients.

OBJECTIVES: The aim of the study was to provide an overview as well as guidance for the diagnosis and treatment of radiation-induced morphea based on current case reports and review articles.

RESULTS AND CONCLUSIONS: Radiation-induced morphea is a rare condition that represents an interdisciplinary challenge for (gynaecological) oncology, radiotherapy and dermatology. Frequent misdiagnoses include infection (erysipelas), cancer recurrence or radiation dermatitis. Early histological diagnosis and the initiation of anti-inflammatory therapy using topical glucocorticoids or calcineurin inhibitors in combination with phototherapy and/or methotrexate are the most relevant success factors for an adequate clinical response.

Translated title of the contribution
Radiation-induced morphea-an overview

Details

Original languageGerman
Pages (from-to)214-217
Number of pages4
JournalDie Dermatologie : Zeitschrift für Dermatologie, Venerologie und verwandte Gebiete
Volume75
Issue number3
Early online date19 Jan 2024
Publication statusPublished - 19 Jan 2024
Peer-reviewedYes

External IDs

ORCID /0000-0002-4330-1861/work/151436388
Scopus 85182677667

Keywords

Sustainable Development Goals

Keywords

  • Neoplasm Recurrence, Local/complications, Humans, Scleroderma, Localized/diagnosis, Breast Neoplasms/complications, Female, Methotrexate/adverse effects, Phototherapy/adverse effects