This study examined linkages between depression symptoms (DEP) and positive adult support (PAS) in female adolescents and the partially mediating influence of eating disturbances (ED). Structural equation modeling was used to establish measurement models for each of the latent constructs, determine the relationships among the latent constructs, and examine the overall model fit of the data. The relationships among the latent constructs of ED, PAS, and DEP were tested using a mediation model. Results indicate that there is a significant, positive relationship between DEP and PAS and that ED are a partial mediator of this relationship. This study provides evidence for the importance of evaluating how ED can influence the trajectory of depression in the lives of adolescent females.