Polyoxazoline: A review article from polymerization to smart behaviors and biomedical applications

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Saba Nemati Mahand - , Iran Polymer and Petrochemical Institute (Author)
  • Sanaz Aliakbarzadeh - , Iran Polymer and Petrochemical Institute (Author)
  • Armaghan Moghaddam - , Iran Polymer and Petrochemical Institute (Author)
  • Abolfazl Salehi Moghaddam - , Lehigh University (Author)
  • Benjamin Kruppke - , Chair of Biomaterials (Author)
  • Mahmoud Nasrollahzadeh - , Iran Polymer and Petrochemical Institute (Author)
  • Hossein Ali Khonakdar - , Chair of Biomaterials, Iran Polymer and Petrochemical Institute (Author)

Abstract

Poly(2-oxazoline) s are emerging innovative biomaterials that show analogous and even preferable properties compared to well-known counterparts, especially poly(ethylene glycol). This polymer can be synthesized in a living and hence controlled manner using the cationic ring-opening polymerization method. In addition, various polyoxazolines are water-soluble or amphiphilic and relatively non-toxic, making them attractive as biomaterials. Polyoxazolines (10 and 20 kDa) are safe when used intravenously to rats and can be used for several biomedical applications. These results from various papers and patents conclude that POx is a favorable biopolymer. The present review aims to highlight the synthesis, structure, and properties of polyoxazolines, such as different derivatives of POx used in tissue engineering. Different polymerization methods and smart behaviors of POx are described as well. Finally, it aims to introduce the significance and potential of POx in biomedical applications like drug delivery, protein delivery, and gene delivery using a number of leading references of recent years.

Details

Original languageEnglish
Article number111484
Number of pages20
JournalEuropean Polymer Journal
Volume178
Publication statusPublished - 5 Sept 2022
Peer-reviewedYes

External IDs

unpaywall 10.1016/j.eurpolymj.2022.111484
WOS 000863065200004

Keywords

Research priority areas of TU Dresden

DFG Classification of Subject Areas according to Review Boards

Keywords

  • Biopolymer, Drug delivery, Gene delivery, Polyoxazoline, Protein delivery, Smart behavior, Stimuli-responsive polymers, Tissue engineering, Stimuli -responsive polymers