Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Physical activity induces adult hippocampal neurogenesis. We here show that the acute up-regulating effect of voluntary wheel running on precursor cell proliferation decreases with continued exercise, but that continued exercise reduces the age-dependent decline in adult neurogenesis. Cell proliferation peaked at 3 days of running. After 32 days of exercise this response returned to baseline. Running-induced proliferation of transiently amplifying progenitor cells led to a consecutive increase in the number of more mature cells. Increasing age reduced adult neurogenesis at 9 months to 50% of the value at 6 weeks and to 17% at the age of 2 years. At both 1 and 2 years, precursor cell divisions remained inducible by physical activity. Exercise from 3 to 9 months of age significantly reduced the age-dependent decline in cell proliferation but (presumably in the absence of additional stimuli) did not maintain net neurogenesis at levels corresponding to a younger age. We propose that physical activity might contribute to successful aging by increasing the potential for neurogenesis represented by the pool of proliferating precursor cells.
Details
Original language | English |
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Pages (from-to) | 1505-1513 |
Number of pages | 9 |
Journal | Neurobiology of aging |
Volume | 27 |
Issue number | 10 |
Publication status | Published - Oct 2006 |
Peer-reviewed | Yes |
External IDs
PubMed | 16271278 |
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ORCID | /0000-0002-5304-4061/work/161408174 |
Keywords
ASJC Scopus subject areas
Keywords
- Adult neurogenesis, Hippocampus, Progenitor cell, Stem cell, Wheel running