Peroxidase-mimicking activity of nanozymes-loaded polymeric artificial organelles potentially active in acidic environment

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Silvia Moreno - , Leibniz Institute of Polymer Research Dresden (Author)
  • Sonia Alex - , Leibniz Institute of Polymer Research Dresden (Author)
  • Laia Lopez Fernandez - , Autonomous University of Barcelona (Author)
  • Uwe Lappan - , Leibniz Institute of Polymer Research Dresden (Author)
  • Susanne Boye - , Leibniz Institute of Polymer Research Dresden (Author)
  • Brigitte Voit - , Chair of Organic Chemistry of Polymers, Leibniz Institute of Polymer Research Dresden, TUD Dresden University of Technology (Author)
  • Dietmar Appelhans - , Leibniz Institute of Polymer Research Dresden (Author)

Abstract

The design of compartments capable of carrying out biological reactions in a local space has provoked enormous interest by providing spatiotemporal and long-term selective control of biological activity. On the other hand, the application of metal-porphyrins in the field of biomedical science as nanozymes is gaining substantial importance. Porphyrins are the most widely studied tetrapyrrole-based compounds because of their important roles in vital biological processes and they possess peculiar photochemical, photophysical, and photo/redox properties. Herein, we demonstrate the use of pH-responsive and photo-crosslinked polymersomes for loading β-cyclodextrin-Hemin complexes as potential peroxidase-mimicking cavity. The loading of catalytic active centers into polymeric vesicles represents a simple and effective strategy for enzyme mimicry. Physicochemical and enzyme-like properties are studied using a variety of characterization methods at different simulated microenvironments. This work offers an improvement of the aqueous solubility of the Hemin molecule, crucial for biomedical applications. In addition, these nanocompartments can be used as artificial radical-producing and hydrogen peroxide-consuming organelles, being able to replace cell functions in different microenvironments. Therefore, these artificial organelles, entrapping nanozymes, could provide promising synergistic and more personalized therapies on demand in modern nanomedicine.

Details

Original languageEnglish
Pages (from-to)1859-1869
Number of pages11
JournalJournal of Polymer Science
Volume61
Issue number16
Early online dateMay 2023
Publication statusPublished - 15 Aug 2023
Peer-reviewedYes

External IDs

Scopus 85158119376
ORCID /0000-0002-4531-691X/work/148608019
Mendeley 4b1f9b86-8bda-3a3a-b911-c6abdd437ad4

Keywords

Keywords

  • Artificial organelles, Nanozyme, Polymeric vesicle, Porphyrins, Redox process, artificial organelles, nanozyme, polymeric vesicle, porphyrins, redox process