Penile cancer – Incidence, mortality, and survival in Saxony, Germany

Research output: Contribution to journalResearch articleContributedpeer-review


  • Olaf Schoffer - , Center for Evidence-Based Healthcare, Technical University of Munich, TUD Dresden University of Technology (Author)
  • Anne Neumann - , Center for Evidence-Based Healthcare, TUD Dresden University of Technology (Author)
  • Roland Stabenow - , Common Cancer Registry (Author)
  • Stefanie Schülein - , Technical University of Munich (Author)
  • Wolf Diether Böhm - , Urology Practice (Author)
  • Andreas Gonsior - , Leipzig University (Author)
  • Lars Christian Horn - , Leipzig University (Author)
  • Christian Kriegel - , Leipzig University (Author)
  • Jens Uwe Stolzenburg - , Leipzig University (Author)
  • Manfred Wirth - , TUD Dresden University of Technology (Author)
  • Stefanie J. Klug - , Technical University of Munich (Author)


Objective: Penile cancer is a rare disease in Europe and North America. Cancer registry data were used to estimate the incidence, mortality, and survival of penile cancer in Saxony, Germany. Methods: Data on incidence were analyzed for the period 1961 to 2012 and mortality for the period 1990 to 2012. Trend analyses of incidence and mortality were performed using joinpoint regression. Survival rates for primary penile cancer (ICD-10 C60) were estimated; overall, by T stage, UICC stage, and by year of diagnosis for the years 1963 to 2012. Results: Age-standardized incidence increased from 1.2 per 100,000 in 1961 to 1.8 per 100,000 in 2012, with a statistically significant increase between 2003 and 2012 (annual percent change: 4.66; 95% confidence interval, CI 0.62–8.86). There was a statistically significant negative trend in mortality between 1990 and 2012 (annual percent change: −3.46, 95% CI −5.21 to −1.67). A total of 430 new cases of penile cancer were registered between 2003 and 2012, with 63% of all penile cancers occurring in men aged 60 to 79 years. Almost half of those cases were located at the glans penis. The overall relative 5-year survival for the years of diagnosis 2003 to 2012 was 72.4% (95% CI 64.8%–80.0%). Relative 5-year survival decreased with higher UICC stages (I: 96%, 95% CI 84.7%–107.3%; II: 86.3%, 95% CI 71.0%–101.5%; III: 39.6%, 95% CI 19.9%–59.3%; IV: 20.3%, 95% CI 2.4%–38.2%). Conclusion: The incidence of penile cancer in Saxony has increased in recent years, while mortality has decreased. However, survival rates have remained constant over time.


Original languageEnglish
Pages (from-to)295.e1-295.e8
JournalUrologic Oncology: Seminars and Original Investigations
Issue number4
Publication statusPublished - Apr 2019

External IDs

PubMed 30595462


Sustainable Development Goals

ASJC Scopus subject areas


  • Abbreviations: ESR, European Standardized Rate, APC, annual percent change, CCR, Common Cancer Registry, DCO, death certificate only, Germany, HPV, human papillomavirus, Incidence, Mortality, NCR, National Cancer Registry, Penile cancer, Saxony, SCC, squamous cell carcinomas, STIKO, the German Standing Committee on Vaccination, Survival, TNM, Tumor-Node-Metastasis Classification of Malignant Tumors, UICC, Union for International Cancer Control, WSR, World Standardized Rate