PDZ-domain-binding sites are common among cadherins

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Fabio Demontis - , Max Planck Institute of Molecular Cell Biology and Genetics (First author)
  • Bianca Habermann - , Max Planck Institute of Molecular Cell Biology and Genetics (Author)
  • Christian Dahmann - , Max Planck Institute of Molecular Cell Biology and Genetics (Author)

Abstract

Cadherins are Ca(2+)-dependent cell adhesion molecules that play fundamental roles in animal development and homeostasis. A number of cadherins contain conserved binding sites for catenins in their cytoplasmic region that are important for the adhesive function of these cadherins by mediating their interaction to the cytoskeleton. However, most cadherins lack apparent binding sites for catenins and their cytoplasmic interacting partners are mostly unknown. In this paper, we show, using bioinformatics, that a number of insect and vertebrate cadherins lacking catenin-binding sites contain conserved consensus sequences for C-terminal PSD-95/Discs-large/ZO-1 (PDZ)-domain-binding sites. This suggests that PDZ-domain-containing proteins are common cytoplasmic interacting partners for cadherins lacking catenin-binding sites.

Details

Original languageEnglish
Pages (from-to)737-741
Number of pages5
JournalDevelopment Genes and Evolution
Volume216
Issue number11
Publication statusPublished - Nov 2006
Peer-reviewedYes
Externally publishedYes

External IDs

Scopus 33750469003

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